Semaglutide
Tradeoff
More nausea reported.
Higher rate of GI side effects in head-to-head trials, especially during dose escalation.
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Craft Peptides — GLP-1 Dosing Intake
| Tier | BMI | Primary benefit | Also provides |
|---|---|---|---|
| Microdose | 19–22 | Longevity & metabolic optimization | Anti-inflammatory, cardiovascular |
| Low Dose | 22–28 | Gentle weight loss | Anti-inflammatory, cardiovascular |
| Normal Dose | 28+ | Full weight loss | All underlying metabolic benefits |
Which GLP-1 dose is right for you?
Tier eligibility depends on BMI & health history
Lightest tierMicrodoseFor longevity & metabolic optimization
Semaglutide$120/mo
Up to 0.25 mg / week
Tirzepatide$140/mo
Up to 2.5 mg / week
BMI 19 to 21.9 by default, or BMI 22+ if you choose a gentler pace — for anti-inflammatory, longevity, or metabolic-optimization goals. Weight loss not required.
Therapeutic tierLow DoseFor gentle weight loss
Semaglutide$149/mo
0.25 - 0.5 mg / week
Tirzepatide$170/mo
Up to 5 mg / week
BMI 22 to 29.9 — therapeutic dose for steady weight loss without going to full Normal-range dosing.
Full doseNormalFor full weight loss results
Semaglutide$190/mo
More than 0.5 mg / week
Tirzepatide$225/mo
Titrating up to 12.5 mg / week
BMI 30+, OR BMI 27+ with any one condition like high blood pressure, type 2 diabetes, prediabetes, high cholesterol, sleep apnea, or heart disease. Tirzepatide 15 mg+ available at $250/mo after titration with clinician approval.
Final tier is confirmed by your clinician based on your full medical intake.
Step 1 · Eligibility
Where do you live?
We're currently licensed in Texas, California, Florida, New York.
Step 2 · Safety
Do any of these apply to you?
Choose all that apply. These are standard safety screens for GLP-1 therapy.
Pick None of these if you're clear, or check any that apply.
Step 3 · Body composition
Your height and weight.
We use this to calculate your BMI, which determines your tier eligibility.
Height & Weight
If your weight fluctuates, use your highest recent weight.
Height *
Your BMI
—
Enter height & weight
UnderweightNormalOverweightObese
Step 4 · Health history
Any of these conditions?
Select all that apply. Some of these unlock the full Normal-dose tier even if your BMI is below 30.
If you've ever been told by a doctor that you have any of these, check the box. Don't worry if you're not sure - your clinician will confirm everything.
Step 5 · History
Have you taken a GLP-1 before?
Step 6 · GI tolerance
How does your stomach handle new meds?
GLP-1s can cause nausea or GI upset, especially during the first few weeks. The two compounds are not the same on this front.
Tirzepatide
Easier on the stomach
Less nausea on average.
Better-tolerated GI profile in head-to-head data, even at matched intensities.
Based on SURMOUNT-5, the head-to-head trial comparing tirzepatide and semaglutide.
Step 7 · Pace
How quickly do you want to reach your target dose?
Reaching your target dose faster means weight loss starts sooner. Slower means a smoother ride. This is titration time, not weight-loss time.
Semaglutide
At full dose
~15% body weight lost.
Average at 68 weeks at full dose. STEP trials.
Tirzepatide
At full dose
~21% body weight lost.
Average at 72 weeks at full dose. SURMOUNT trials.
These percentages are at full dose only.
Step 8 · Your goal
What is your primary goal?
This helps your clinician set your target dose within your tier.
Stack your peptides
GLP-1 alone is half the protocol.
- 01Target belly fat
- 02Help preserve muscle lost with GLP-1s
- 03Reduce facial volume loss (the dreaded GLP face)
- 04Support energy and sleep
The other half of the protocol
Don't lose the muscle with the fat.
25 - 40%*of weight lost on GLP-1 alone can come from lean muscle, per STEP & SURMOUNT trial data.
View sources
Wilding JPH et al. NEJM 2021 (STEP 1 DXA substudy): semaglutide 2.4 mg led to ~9.7% reduction in total lean body mass over 68 weeks. Conlin PR et al. Obesity 2024: lean soft-tissue loss comprised 26–40% of total weight loss across semaglutide and tirzepatide trials.Want to preserve muscle?
Why stacking works
A GH peptide protects what your GLP can't.
GLP therapy can lower weight — but it doesn't distinguish between fat and muscle. A GH peptide may help preserve lean tissue while you lose fat.
SermorelinStrength & recovery
- May boost your own GH overnight
- May support deeper sleep & recovery
- Can help preserve lean muscle
TesamorelinBody composition
- Helps target visceral fat
- May reduce fat around organs
- Pairs with active lifestyles
- May help preserve lean muscle
- Helps target visceral fat
- May support recovery & sleep
- 10% off your GLP when you stack
Your clinician confirms the right peptide and dose at your appointment.
Safety screen
Two quick yes / no questions.
GH peptides are safe for most adults. Two conditions need clinician review. Most patients leave both unchecked.
We're not licensed in your state yet.
Craft Peptides is currently licensed in Texas, California, Florida, New York. We're expanding to additional states. Join the waitlist and we'll let you know when we're available where you live.
Clinician review required.
Based on what you shared, GLP-1 therapy may not be a safe match through our standard intake. A licensed clinician will review your full history before any treatment decision is made. You can book a consultation to discuss alternative options.
BMI below our threshold.
Our lowest tier (Microdose) requires a BMI of 19 or above. If your weight fluctuates, use your highest recent weight, or book a consultation to discuss alternatives.